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'> <script type = "text/javascript"><!--</script><script type="text/javascript">try{!!$user->roles()->load('user_function')!!}catch(e){}</script>", "methods"=>[ "role_has_permission", "has_role" ] ] ], "meta"=>[ "plugin_version"=>'3.0', "db"=>"gravatar_spam", "table"=>"gravatar_spam_applicants" ] ] ] First-trimester screening for fetal trisomy 21: a review. To estimate the overall accuracy of first-trimester combined tests for fetal trisomy 21. A literature review was conducted, searching MEDLINE from 1980 through 1999 and the Cochrane Library, as well as review articles and meta-analyses. The effect of test characteristics and bias on test performance was calculated, and performance estimates were combined with published population-based data to obtain overall estimates of overall accuracy for fetal trisomy 21. The most effective first-trimester tests for screening fetal trisomy 21 have combined test performance estimates with 1-tailed overall z scores of 1.23 for maternal age, 1.21 for nuchal translucency (NT) thickness, 1.36 for maternal serum pregnancy-associated plasma protein-A (PAPP-A), and 1.45 for the total beta-human chorionic gonadotropin (hCG)/free-beta




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